Medications


Gilteritinib tablets

What is this medicine?

GILTERITINIB (gil te ri ti nib) is a medicine that targets proteins in cancer cells and stops the cancer cells from growing. It is used to treat acute myelogenous leukemia.

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You can take this medicine with or without food. However, you should always take it the same way. Do not cut, crush, or chew this medicine. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • blurred vision

  • breathing problems

  • changes in vision

  • confusion

  • cough

  • fever or chills, sore throat

  • seizures

  • signs and symptoms of a dangerous change in heartbeat or heart rhythm like chest pain; dizziness; fast, irregular heartbeat; palpitations; feeling faint or lightheaded; falls, breathing problems

  • stomach pain

  • swelling of arms and legs

  • trouble passing urine or change in the amount of urine

Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):

  • constipation

  • joint pain

  • muscle pain

  • nausea

  • tiredness

What may interact with this medicine?

This medicine may interact with the following medications:

  • apalutamide

  • antiviral medicines for HIV or AIDS

  • certain antibiotics like clarithromycin, chloramphenicol, telithromycin, and dalfopristin; quinupristin

  • certain antidepressants like escitalopram, fluoxetine, and sertraline

  • certain antifungals like itraconazole, ketoconazole, posaconazole, and voriconazole

  • certain medicines for seizures like carbamazepine, fosphenytoin/phenytoin, phenobarbital, and primidone

  • conivaptan

  • grapefruit juice

  • idelalisib

  • lumacaftor; ivacaftor

  • mifepristone

  • nefazodone

  • ribociclib

  • rifampin

  • St.John's wort

What if I miss a dose?

If you miss a dose, take it as soon as you can. If your next dose is to be taken in less than 12 hours, then do not take the missed dose. Take the next dose at your regular time. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Keep this medicine in the original container. Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • an unusual or allergic reaction to gilteritinib, other medicines, foods, dyes, or preservatives

  • heart disease

  • history of irregular heartbeat

  • history of low levels of potassium or magnesium in the blood

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

You may need blood work done while you are taking this medicine.

Do not become pregnant while taking this medicine or for a least 6 months after stopping it. Women should inform their healthcare professional if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine or for at least 4 months after stopping it. There is a potential for serious effects to an unborn child. Talk to your healthcare professional for more information.

Do not breast-feed an infant while taking this medicine or for at least 2 months after stopping it.


NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2019 Elsevier
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