Medications


Ivosidenib tablets

What is this medicine?

IVOSIDENIB (EYE voe SID e nib) is a medicine that targets proteins in cancer cells and stops the cancer cells from growing. It is used to treat acute myelogenous leukemia.

How should I use this medicine?

Take this medicine by mouth with a full glass of water. Swallow the tablets whole. Do not cut, crush or chew this medicine. Follow the directions on the prescription label. You can take it with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breathing problems

  • changes in vision

  • cough

  • fever

  • mouth sores

  • numbness or tingling in any part of your body

  • signs and symptoms of a dangerous change in heartbeat or heart rhythm like chest pain; dizziness; fast or irregular heartbeat; palpitations; feeling faint or lightheaded, falls; breathing problems

  • signs and symptoms of low blood pressure like dizziness; feeling faint or lightheaded, falls; unusually weak or tired

  • signs and symptoms of low magnesium like muscle cramps, pain, or weakness; tremors; seizures; or fast, irregular heartbeat

  • swelling of arms and legs

  • trouble passing urine or change in the amount of urine

  • unusually weak or tired

Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):

  • decreased appetite

  • constipation

  • diarrhea

  • joint pain

  • muscle pain

  • nausea

  • tiredness

  • vomiting

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • cisapride

  • dofetilide

  • dronedarone

  • pimozide

  • thioridazine

This medicine may interact with the following medications:

  • antiviral medicines for HIV or AIDS

  • carbamazepine

  • certain medicines for fungal infections like fluconazole, itraconazole, and ketoconazole

  • female hormones, like estrogens or progestins and birth control pills, patches, rings, or injections

  • certain medicines for irregular heart beat like amiodarone, encainide, flecainide, propafenone, quinidine

  • grapefruit juice

  • other medicines that prolong the QT interval (cause an abnormal heart rhythm)

  • phenobarbital

  • primidone

  • rifampin

  • St. John's wort

What if I miss a dose?

If you vomit after taking a dose, do not take an additional dose. Take your next dose at your usual time. If you miss a dose, take it as soon as you can as long as there are at least 12 hours before your next dose. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • Guillain-Barre syndrome

  • heart disease

  • history of irregular heartbeat

  • liver disease

  • low levels of sodium, potassium or magnesium in the blood

  • nervous system problems

  • an unusual or allergic reaction to ivosidenib, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine. You may need blood work done while you are taking this medicine.

Do not become pregnant while taking this medication. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Men should not father a child while taking this medicine. Birth control pills may not work properly while you are taking this medicine. Talk with your doctor or health care professional about your birth control options while taking this medicine. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine or for 1 month after the last dose.

This medicine may interfere with the ability to have a child. Talk with your doctor or health care professional if you are concerned about your fertility.


NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2019 Elsevier
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